CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10756
Family Name Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4-methoxyphenyl)-4-[(1S)-1-cyclopropylpropyl]-2-methylpyrido[2,3-b]pyrazin-3-one family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00404227 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Binder Superfamily 9
Class Class 513

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Corticotropin-releasing factor receptor 1 ligand 4-(2-chloro-5... 1 3
Corticotropin-releasing factor receptor 1 ligand 8-(5-chloro-2... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404218 CHEMBL2058593 Bioactive 8-(2-chloro-5-fluoro-4-methoxyphenyl)-4-[(1R)-1-cyclopropylpropyl]-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404231 CHEMBL2057477 Bioactive 4-(dicyclopropylmethyl)-8-(4-methoxy-2-methylphenyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404224 CHEMBL2058589 Bioactive 8-(2-chloro-4-ethoxy-5-methylphenyl)-4-(1-cyclopropylpropyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404230 CHEMBL2057478 Bioactive 8-(2-chloro-5-fluoro-4-methoxyphenyl)-4-(1-methoxybutan-2-yl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404223 CHEMBL2058598 Bioactive 8-(4-chloro-2-methoxy-5-methylphenyl)-4-(1-cyclopropylpropyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404229 CHEMBL2057479 Bioactive 8-(2-chloro-5-fluoro-4-methoxyphenyl)-4-(1-cyclopropyl-2-methoxyethyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404222 CHEMBL2058594 Bioactive 4-[(1R)-1-cyclopropylpropyl]-8-(5-fluoro-4-methoxy-2-methylphenyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404228 CHEMBL2058335 Bioactive 8-[2-chloro-4-(difluoromethoxy)phenyl]-4-[(1S)-1-cyclopropylpropyl]-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404227 CHEMBL2058336 Bioactive 8-(2-chloro-4-methoxyphenyl)-4-[(1S)-1-cyclopropylpropyl]-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404220 CHEMBL2058591 Bioactive 8-(5-chloro-4-methoxy-2-methylphenyl)-4-[(1R)-1-cyclopropylpropyl]-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404226 CHEMBL2058337 Bioactive 8-(2-chloro-4-methoxyphenyl)-4-[(1R)-1-cyclopropylpropyl]-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404219 CHEMBL2058592 Bioactive 8-[5-chloro-4-(difluoromethoxy)-2-methylphenyl]-4-(1-cyclopropylpropyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404225 CHEMBL2058338 Bioactive 8-(2-chloro-4-methoxy-5-methylphenyl)-4-(1-cyclopropylpropyl)-2-methylpyrido[2,3-b]pyrazin-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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