CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10766
Family Name Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethanol family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00404285 Functional Category Bioactive
Superfamily Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-279700 Superfamily
Class Class 2257

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 0
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 1 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Cannabinoid receptor 2 ligand 4-[6-(2,3-dichlorophenyl)-1,2,4-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404285 CHEMBL2057801 Bioactive 2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethanol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46156 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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