CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10773
Family Name Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-(2-morpholin-4-ylpyrimidin-4-yl)oxyphenyl]methyl]urea family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00404311 Functional Category Bioactive
Superfamily Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Superfamily
Class Class 851

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
DCC-2036 family 2 5
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Neuropeptide Y receptor type 5 ligand 3-[1-(2-fluorophenyl)pyr... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404314 CHEMBL2058048 Bioactive 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-chloro-2-(2-morpholin-4-ylpyrimidin-4-yl)oxyphenyl]methyl]urea
CFAMM00404313 CHEMBL2058051 Bioactive 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[3,5-difluoro-2-(2-morpholin-4-ylpyrimidin-4-yl)oxyphenyl]methyl]urea
CFAMM00404311 CHEMBL2058047 Bioactive 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-(2-morpholin-4-ylpyrimidin-4-yl)oxyphenyl]methyl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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