CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10774
Family Name Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyclopropylpropyl]-8-(2,4-dichlorophenyl)-2-methylpyrido[2,3-b]pyrazin-3-one family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00404322 Functional Category Bioactive
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand Bctc Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Corticotropin-releasing factor receptor 1 ligand 4-(1-cyclopro... 3 0
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
B1 bradykinin receptor ligand N-[2-[[4-(2-chlorophenyl)-4-cyan... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1


External ID

Functional Category

Molecule Name

CFAMM00404316 CHEMBL2058329 Bioactive 8-(2,4-dichlorophenyl)-4-[(2R)-1-methoxybutan-2-yl]-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404322 CHEMBL2058069 Bioactive 4-[(1R)-1-cyclopropylpropyl]-8-(2,4-dichlorophenyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404319 CHEMBL2058596 Bioactive 8-[2-chloro-4-(dimethylamino)-5-fluorophenyl]-4-(1-cyclopropylpropyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404318 CHEMBL2058327 Bioactive 4-(1-cyclopropylbutyl)-8-(2,4-dichlorophenyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404317 CHEMBL2058326 Bioactive 4-[(1S)-1-cyclopropylpropyl]-8-(2,4-dichlorophenyl)-2-methylpyrido[2,3-b]pyrazin-3-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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