CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10777
Family Name Corticotropin-releasing factor receptor 1 ligand 4-(1-cyclopropylpropyl)-8-(2,4-dimethylphenyl)-2-methylpyrido[2,3-b]pyrazin-3-one family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00404343 Functional Category Bioactive
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand Bctc Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
Class II cytokine receptor Ligand IL-10 Family 7 45
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Substance-P receptor ligand Netupitant family 5 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Translocator protein inhibitor CHEMBL2331870 family 2 0
B1 bradykinin receptor ligand N-[2-[[4-(2-chlorophenyl)-4-cyan... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1


External ID

Functional Category

Molecule Name

CFAMM00404344 CHEMBL2058597 Bioactive 4-chloro-5-[4-(1-cyclopropylpropyl)-2-methyl-3-oxopyrido[2,3-b]pyrazin-8-yl]-2-methylbenzonitrile
CFAMM00404343 CHEMBL2058331 Bioactive 4-(1-cyclopropylpropyl)-8-(2,4-dimethylphenyl)-2-methylpyrido[2,3-b]pyrazin-3-one
CFAMM00404342 CHEMBL2058332 Bioactive 4-(1-cyclopropylpropyl)-2-methyl-8-(2,4,5-trimethylphenyl)pyrido[2,3-b]pyrazin-3-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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