CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10786
Family Name Poly [ADP-ribose] polymerase 1 inhibitor 2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-8-yl)methyl]benzamide family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00404377 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 and Cellular tumor antigen p53 Binder Superfamily
Class Class 3150

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Poly [ADP-ribose] polymerase 1 Inhibitor KU-0059436 Family 21 45
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 7 9
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Histamine H3 receptor ligand 2-methyl-6-[4-[(2S)-2-(pyrrolidin... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-phe... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor Acylpiperazine analog... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor 3-[[4-fluoro-3-[4-(2-... 15 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404379 CHEMBL2058921 Bioactive 4-[2-fluoro-5-[(5-oxo-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-8-yl)methyl]benzoyl]-N,N-dimethylpiperazine-1-carboxamide
CFAMM00404385 CHEMBL2058912 Bioactive 8-[[3-(4-aminopiperidine-1-carbonyl)-4-fluorophenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00404378 CHEMBL2058922 Bioactive 8-[[4-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)phenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00404384 CHEMBL2058914 Bioactive 8-[[4-fluoro-3-(4-methylpiperazine-1-carbonyl)phenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00404377 CHEMBL2058693 Bioactive 2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-8-yl)methyl]benzamide
CFAMM00404383 CHEMBL2058915 Bioactive 8-[[3-(4-cyclopentylpiperazine-1-carbonyl)-4-fluorophenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00404376 CHEMBL2058692 Bioactive 2-fluoro-5-[(5-oxo-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-8-yl)methyl]-N-(2-pyrrolidin-1-ylethyl)benzamide
CFAMM00404382 CHEMBL2058916 Bioactive 8-[[4-fluoro-3-(3-oxopiperazine-1-carbonyl)phenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00404375 CHEMBL2058690 Bioactive N-ethyl-2-fluoro-5-[(5-oxo-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-8-yl)methyl]benzamide
CFAMM00404381 CHEMBL2058918 Bioactive 8-[[3-(4-acetylpiperazine-1-carbonyl)-4-fluorophenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00404380 CHEMBL2058919 Bioactive 8-[[4-fluoro-3-[4-(2,2,2-trifluoroacetyl)piperazine-1-carbonyl]phenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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