CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10793
Family Name Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide family
No. of Seeds 14 No. of Other Members 12
Family Centroid CFAMM00404489 Functional Category Bioactive
Superfamily Translocator protein and Thyrotropin receptor Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Mizolastine Family 14 603
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
BIBT986 family 7 96
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Toll-like receptor 7 Ligand GS-9620 Family 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 5 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
P2X purinoceptor 7 inhibitor N-[(3-chloro-2-methylphenyl)methy... 7 0
Melanin-concentrating hormone receptor 1 ligand (E)-3-(4-chlor... 3 7
Melanin-concentrating hormone receptor 1 ligand (E)-3-(4-chlor... 6 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404466 CHEMBL2058819 Bioactive N-butan-2-yl-N-methyl-4-phenylquinazoline-2-carboxamide
CFAMM00404485 CHEMBL2059046 Bioactive azepan-1-yl-[4-(2-chlorophenyl)quinazolin-2-yl]methanone
CFAMM00404491 CHEMBL2059061 Bioactive N-[(2S)-butan-2-yl]-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide
CFAMM00404477 CHEMBL2059055 Bioactive 6-chloro-4-(4-chlorophenyl)-N,N-dihexylquinazoline-2-carboxamide
CFAMM00404490 CHEMBL2059041 Bioactive 4-(2-chlorophenyl)-N-methyl-N-(2-methylpropyl)quinazoline-2-carboxamide
CFAMM00404470 CHEMBL2059063 Bioactive N-[(2S)-butan-2-yl]-4-(4-chlorophenyl)-N-methylquinazoline-2-carboxamide
CFAMM00404483 CHEMBL2059048 Bioactive N-butan-2-yl-4-(4-chlorophenyl)-N-methylquinazoline-2-carboxamide
CFAMM00404476 CHEMBL2059059 Bioactive N-[(2S)-butan-2-yl]-N-methyl-4-phenylquinazoline-2-carboxamide
CFAMM00404489 CHEMBL2059040 Bioactive N-butan-2-yl-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide
CFAMM00404482 CHEMBL2059051 Bioactive 4-(4-chlorophenyl)-N,N-dihexylquinazoline-2-carboxamide
CFAMM00404469 CHEMBL2059062 Bioactive N-[(2R)-butan-2-yl]-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide
CFAMM00404468 CHEMBL2059060 Bioactive N-[(2R)-butan-2-yl]-N-methyl-4-phenylquinazoline-2-carboxamide
CFAMM00404474 CHEMBL2058825 Bioactive N,N-dihexyl-4-phenylquinazoline-2-carboxamide
CFAMM00404467 CHEMBL2059064 Bioactive N-[(2R)-butan-2-yl]-4-(4-chlorophenyl)-N-methylquinazoline-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

39093 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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