CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10799
Family Name Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-ylpiperazin-1-yl)pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00404518 Functional Category Bioactive with Natural Product
Superfamily Dipeptidyl peptidase 4 Inhibitor Teneligliptin Superfamily
Class Class 1303

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Translocator protein Inhibitor Emapunil Family 7 89
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(6-aminopyr... 1 4
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Reverse transcriptase/RNaseH inhibitor AC1MHDLR family 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Coagulation factor X inhibitor (6S,8aS)-N-[(6-amino-2-methylpy... 1 1
Prothrombin and Transmembrane protease serine 11D inhibitor (2... 1 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-2-ylpi... 1 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Cathepsin K inhibitor CHEMBL2163360 family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-pyridin-2-ylpip... 4 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Cathepsin K inhibitor SureCN4138062 family 7 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 1 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Glucokinase inhibitor (2S)-2-(4-cyclobutylsulfonyl-2-oxopyridi... 2 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404518 CHEMBL2058973 Bioactive [(2S,4S)-4-(4-isoquinolin-1-ylpiperazin-1-yl)pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
CFAMM00404517 CHEMBL2058974 Bioactive [(2S,4S)-4-[4-(4-chloroisoquinolin-1-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
CFAMM00404516 CHEMBL2058975 Bioactive 1-[4-[(3S,5S)-5-(1,3-thiazolidine-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl]isoquinoline-4-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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