Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members HIV protease Inhibitor Indinavir Family 36 211 HIV protease Inhibitor Saquinavir Family 64 428 HIV-1 protease Inhibitor Atazanavir Family 16 58 Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75 Coagulation factor X Inhibitor Otamixaban Family 9 21 CP-18770 family 6 27 Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70 Integrin beta-3 Inhibitor Elarofiban Family 28 45 Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12 Integrin beta-1 and Integrin alpha-4 Inhibitor MK-0668 Family 46 20 Endothelin B receptor Ligand IRL-2500 Family 34 87 Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0 Pol polyprotein inhibitor AC1LAD48 family 19 5 Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 19 53 Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8 Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14 Beta-secretase 1 inhibitor 1-N-[(1S,2S)-3-(3,5-difluorophenyl)... 2 16 Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5 Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0 Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4 Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4 C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4 Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3 Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1 Pol polyprotein inhibitor Lysine Sulfonamide 6h family 1 1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5 Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0 cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2 Pol polyprotein inhibitor AC1LAHRX family 4 0 Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0 Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5930118 ... 15 30 Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1 Beta-secretase 1 and Cathepsin B inhibitor SureCN14347937 family 4 1 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1 Nicotinamide phosphoribosyltransferase inhibitor 1-[4-(8-oxa-3... 5 4 Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4 Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(butyl... 2 4 Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0 Pol polyprotein inhibitor 169168-47-2 family 4 0 Pol polyprotein inhibitor 183854-15-1 family 3 0 Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1 Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5 Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2 Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1 Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 4-(5,7... 2 9 Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2 Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 1 0 Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 7 4 Prothrombin inhibitor N-[(1S)-2-[4-(2-fluoroethyl)piperidin-1-... 5 0 Prothrombin inhibitor 2-[(3S)-4-[4-(2-fluoroethyl)piperidin-1-... 1 0 Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[4-[3-[[... 1 0 Integrin alpha-V inhibitor (2R)-3-(pyridine-3-carbonylamino)-2... 1 0 Caspase-3 inhibitor Inhibitor 55 family 1 1 Pol polyprotein inhibitor AC1LA6OV family 1 2
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00404683 CHEMBL164664 Bioactive
N-[(2S)-3-(4-aminophenyl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-4-[[(2S)-1-(2-hydroxyethoxy)-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide CFAMM00404684 CHEMBL349917 Bioactive
N-[(2S)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]-4-[[(2S)-1-(2-hydroxyethoxy)-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide CFAMM00404677 CHEMBL416528 Bioactive
N-[(1S)-2-[4-(2-fluoroethyl)piperidin-1-yl]-2-oxo-1-pyridin-2-ylethyl]-4-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide CFAMM00404682 CHEMBL120887 Bioactive
N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2S)-1-(2-hydroxyethylamino)-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide CFAMM00404680 CHEMBL121950 Bioactive
N-[(2S)-3-(4-aminophenyl)-1-[4-(2-chloroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide CFAMM00404673 CHEMBL24571 Bioactive
(2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-oxo-5-(3-pyridin-3-ylpropylamino)pentan-2-yl]-2-[[(2S)-2-[[2-(1,1-dioxo-2,3-dihydro-1-benzothiophen-3-yl)acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide CFAMM00404686 CHEMBL120761 Bioactive
N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2S)-1-(2-hydroxyethoxy)-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide CFAMM00404690 19970709 Patent Compound
AGN-PC-02TBK2 CFAMM00404675 19970738 Patent Compound
AGN-PC-02TBKT CFAMM00404668 19970660 Patent Compound
AGN-PC-02TBIU CFAMM00404674 19970636 Patent Compound
AGN-PC-02TBI8 CFAMM00404679 19970560 Patent Compound
AGN-PC-02TBG8 CFAMM00404685 19970830 Patent Compound
AGN-PC-02TBNB CFAMM00404678 19970444 Patent Compound
AGN-PC-02TBD4 CFAMM00404671 57040512 Patent Compound
AGN-PC-0BNPE3
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
