CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10821
Family Name Pol polyprotein inhibitor AC1LAHQ9 family
No. of Seeds 8 No. of Other Members 15
Family Centroid CFAMM00404676 Functional Category Bioactive
Superfamily Integrin beta-3 Inhibitor L-746233 Superfamily
Class Class 2080

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
HIV-1 protease Inhibitor Atazanavir Family 16 58
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Coagulation factor X Inhibitor Otamixaban Family 9 21
CP-18770 family 6 27
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Integrin beta-1 and Integrin alpha-4 Inhibitor MK-0668 Family 46 20
Endothelin B receptor Ligand IRL-2500 Family 34 87
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 19 53
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Beta-secretase 1 inhibitor 1-N-[(1S,2S)-3-(3,5-difluorophenyl)... 2 16
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Pol polyprotein inhibitor Lysine Sulfonamide 6h family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5930118 ... 15 30
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347937 family 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Nicotinamide phosphoribosyltransferase inhibitor 1-[4-(8-oxa-3... 5 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(butyl... 2 4
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor 169168-47-2 family 4 0
Pol polyprotein inhibitor 183854-15-1 family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 4-(5,7... 2 9
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 1 0
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 7 4
Prothrombin inhibitor N-[(1S)-2-[4-(2-fluoroethyl)piperidin-1-... 5 0
Prothrombin inhibitor 2-[(3S)-4-[4-(2-fluoroethyl)piperidin-1-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[4-[3-[[... 1 0
Integrin alpha-V inhibitor (2R)-3-(pyridine-3-carbonylamino)-2... 1 0
Caspase-3 inhibitor Inhibitor 55 family 1 1
Pol polyprotein inhibitor AC1LA6OV family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404672 CHEMBL379751 Bioactive AC1LAHS6
CFAMM00404670 CHEMBL378829 Bioactive N-[(2S)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-1-oxo-3,3-diphenylpropan-2-yl]-4-methylpyridine-3-carboxamide
CFAMM00404676 CHEMBL261952 Bioactive AC1LAHQ9
CFAMM00404689 CHEMBL378044 Bioactive AC1LAHS9
CFAMM00404669 CHEMBL208879 Bioactive AC1LAHT9
CFAMM00404688 CHEMBL205968 Bioactive AC1LAHS0
CFAMM00404681 CHEMBL208724 Bioactive AC1LAHQC
CFAMM00404687 CHEMBL377826 Bioactive 4-amino-N-[(2S)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-1-oxo-3,3-diphenylpropan-2-yl]pyridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27668 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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