CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10826
Family Name Smoothened homolog and Mitogen-activated protein kinase 14 inhibitor N-[2-methyl-5-(5-methyl-1H-imidazol-2-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide family
No. of Seeds 7 No. of Other Members 11
Family Centroid CFAMM00404729 Functional Category Bioactive with Natural Product
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Smoothened homolog Inhibitor LDE225 Family 3 76
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
MK-6096 family 3 69
Eluxadoline family 4 85
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 1
Translocator protein inhibitor AGN-PC-080ILF family 9 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Histamine H3 receptor ligand SureCN7251693 family 3 1
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
P2Y purinoceptor 1 inhibitor N-[2-(2-tert-butylphenoxy)pyridin... 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404728 CHEMBL2059868 Bioactive N-[2-methyl-5-(5-methyl-1H-imidazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404733 CHEMBL2059863 Bioactive N-[2-methyl-5-[5-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404732 CHEMBL2059862 Bioactive N-[5-(1,5-dimethylimidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404731 CHEMBL2059867 Bioactive N-[2-methyl-5-(2-methyl-1H-imidazol-5-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404744 CHEMBL2059859 Bioactive N-[5-(1H-benzimidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404730 CHEMBL2059866 Bioactive N-[2-methyl-5-(1-methylimidazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404729 CHEMBL2059864 Bioactive N-[2-methyl-5-(5-methyl-1H-imidazol-2-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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