CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10835
Family Name Melanin-concentrating hormone receptor 1 and Potassium voltage-gated channel subfamily H member 2 ligand N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-7-fluoro-4-oxochromene-2-carboxamide family
No. of Seeds 12 No. of Other Members 53
Family Centroid CFAMM00403663 Functional Category Bioactive with Natural Product
Superfamily Melanin-concentrating hormone receptor 1 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily 3
Class Class 725

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Hydrastine family 6 115
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Heat shock protein 90, putative Inhibitor KW-2478 Family 1 14
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Histamine H3 receptor Ligand A-317920 Family 9 240
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Acetylcholinesterase inhibitor [3-[[methyl-[7-[[(2E)-1-oxo-2-[... 2 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
D(2) dopamine receptor and D(3) dopamine receptor ligand 5-bro... 3 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Acetylcholinesterase and Cholinesterase inhibitor (1S,3R)-3-(b... 1 16
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Cathepsin D and Plasmepsin-2 inhibitor 1-acetyl-N-[2-(1,3-benz... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Acetylcholinesterase and Cholinesterase inhibitor Xanthostigmi... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 20
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Nuclear receptor subfamily 1 group D member 1 ligand [3-[(3,4-... 2 0
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
Acetylcholinesterase and Butyrylcholinesterase inhibitor (2Z)-... 2 10
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
Stilbenes Metabolite (Z)-Narceine imide Family 1 1
Putative NP ZINC02127056 Family 4 1
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404829 CHEMBL387178 Bioactive SureCN6333446

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27277 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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