CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1087
Family Name Pol polyprotein inhibitor 2-[(2R,3S)-3-[[(2R)-3-(benzenesulfinyl)-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]-N-tert-butylbenzamide family
No. of Seeds 15 No. of Other Members 15
Family Centroid CFAMM00319297 Functional Category Bioactive
Superfamily Pol polyprotein Binder Superfamily 6
Class Class 2411

Cousin Family NamesSeedsMembers
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor SureCN8293614 family 2 0
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Pol polyprotein inhibitor AC1LALX3 family 2 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family 9 4
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Beta-3 adrenergic receptor ligand SureCN4584432 family 5 2
Pol polyprotein inhibitor Enantiomer of AG1284 family 7 1
Pol polyprotein inhibitor AC1LALY0 family 1 5
Pol polyprotein inhibitor AC1L9TA2 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00319291 CHEMBL11426 Bioactive N-tert-butyl-2-[(2R,3S)-3-[[(2R)-3-(4-fluorophenyl)sulfanyl-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]benzamide
CFAMM00319297 CHEMBL11137 Bioactive 2-[(2R,3S)-3-[[(2R)-3-(benzenesulfinyl)-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]-N-tert-butylbenzamide
CFAMM00319277 CHEMBL267092 Bioactive 2-[(2R,3S)-3-[[(2R)-3-(benzenesulfonyl)-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]-N-tert-butylbenzamide
CFAMM00319290 CHEMBL276656 Bioactive N-tert-butyl-2-[(2R,3S)-3-[[(2R)-3-(4-fluorophenyl)sulfonyl-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]benzamide
CFAMM00319296 CHEMBL273368 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-naphthalen-2-ylsulfinylpropanoyl]amino]-4-phenylbutyl]benzamide
CFAMM00319276 CHEMBL274186 Bioactive N-tert-butyl-2-[(2R,3S)-3-[[(2R)-3-(4-chlorophenyl)sulfonyl-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]benzamide
CFAMM00319275 CHEMBL418528 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-[4-(trifluoromethyl)phenyl]sulfinylpropanoyl]amino]-4-phenylbutyl]benzamide
CFAMM00319288 CHEMBL11421 Bioactive N-tert-butyl-2-[(2R,3S)-3-[[(2R)-3-(4-fluorophenyl)sulfinyl-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]benzamide
CFAMM00319301 CHEMBL406991 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-naphthalen-1-ylsulfanylpropanoyl]amino]-4-phenylbutyl]benzamide
CFAMM00319294 CHEMBL277985 Bioactive D-Cysteine Analog 15c
CFAMM00319274 CHEMBL276379 Bioactive 2-[(2R,3S)-3-[[(2R)-2-acetamido-3-naphthalen-2-ylsulfonylpropanoyl]amino]-2-hydroxy-4-phenylbutyl]-N-tert-butylbenzamide
CFAMM00319300 CHEMBL11050 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-naphthalen-2-ylsulfanylpropanoyl]amino]-4-phenylbutyl]benzamide
CFAMM00319293 CHEMBL274569 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-[4-(trifluoromethyl)phenyl]sulfonylpropanoyl]amino]-4-phenylbutyl]benzamide
CFAMM00319279 CHEMBL11143 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-naphthalen-1-ylsulfonylpropanoyl]amino]-4-phenylbutyl]benzamide
CFAMM00319298 CHEMBL11116 Bioactive N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2R)-2-(methanesulfonamido)-3-naphthalen-1-ylsulfinylpropanoyl]amino]-4-phenylbutyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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