CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10878
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform inhibitor 2-[(1-cyclopropyl-5-fluorobenzimidazol-2-yl)methyl]-6-morpholin-4-yl-1H-pyrimidin-4-one family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00405125 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Prelamin-A/C Binder Superfamily 2
Class Class 3587

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
SB989 family 17 91
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 1 4
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Urokinase plasminogen activator surface receptor ligand ethyl ... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 5
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Pyruvate kinase PKM inhibitor 2-(benzimidazol-1-ylmethyl)-6-me... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00405125 CHEMBL2064341 Bioactive 2-[(1-cyclopropyl-5-fluorobenzimidazol-2-yl)methyl]-6-morpholin-4-yl-1H-pyrimidin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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