CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10898
Family Name Epidermal growth factor receptor ligand SureCN4454332 family
No. of Seeds 18 No. of Other Members 5
Family Centroid CFAMM00405241 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Dihydrofolate reductase Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
AP26113 family 16 90
MK-6096 family 3 69
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Aurora kinase A inhibitor SureCN4289024 family 1 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Transient receptor potential cation channel subfamily V member... 2 0
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3


External ID

Functional Category

Molecule Name

CFAMM00405245 CHEMBL208048 Bioactive SureCN4443438
CFAMM00405248 CHEMBL382823 Bioactive SureCN4449109
CFAMM00405230 CHEMBL461968 Bioactive (2S)-2-[[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]propanamide
CFAMM00405238 CHEMBL206783 Bioactive SureCN5130963
CFAMM00405236 CHEMBL517130 Bioactive SureCN4445101
CFAMM00405244 CHEMBL472945 Bioactive (2S)-2-[[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-propan-2-ylamino]propanamide
CFAMM00405247 CHEMBL425601 Bioactive AGN-PC-00BMWL
CFAMM00405229 CHEMBL461967 Bioactive (2R)-N-[[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]-1-methylpiperidine-2-carboxamide
CFAMM00405235 CHEMBL207815 Bioactive AGN-PC-00AWBU
CFAMM00405243 CHEMBL208118 Bioactive SureCN4447196
CFAMM00405242 CHEMBL208292 Bioactive SureCN5121268
CFAMM00405251 CHEMBL207235 Bioactive SureCN5122749
CFAMM00405233 CHEMBL461795 Bioactive (3R)-1-[[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]pyrrolidine-3-carboxamide
CFAMM00405241 CHEMBL207687 Bioactive SureCN4454332
CFAMM00405250 CHEMBL207130 Bioactive AGN-PC-00CT5K
CFAMM00405240 CHEMBL207445 Bioactive SureCN4455126
CFAMM00405231 CHEMBL207718 Bioactive SureCN4443042
CFAMM00405239 CHEMBL206955 Bioactive SureCN5124667

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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