CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10904
Family Name Disintegrin and metalloproteinase domain-containing protein 17 inhibitor N-[(1R,2R)-2-(hydroxycarbamoyl)cyclohexyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide family
No. of Seeds 16 No. of Other Members 2
Family Centroid CFAMM00405290 Functional Category Bioactive
Superfamily Disintegrin and metalloproteinase domain-containing protein 17 Binder Superfamily 2
Class Class 297

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Coagulation factor X Inhibitor Apixaban Family 34 52
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Turofexorate Isopropyl family 6 29
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 15 2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 44 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 3 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
NS5B protein inhibitor AC1O5AET family 3 1
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-met... 3 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Disintegrin and metalloproteinase domain-containing protein 17... 5 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 9 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1
Bile acid receptor ligand SureCN1243717 family 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00405291 CHEMBL254108 Bioactive N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
CFAMM00405284 CHEMBL401824 Bioactive N-[(1R,2S)-4,4-difluoro-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
CFAMM00405290 CHEMBL253909 Bioactive N-[(1R,2R)-2-(hydroxycarbamoyl)cyclohexyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
CFAMM00405289 CHEMBL404083 Bioactive (2S,3R)-N-hydroxy-3-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]oxane-2-carboxamide
CFAMM00405282 CHEMBL206930 Bioactive AGN-PC-01V8JU
CFAMM00405288 CHEMBL251994 Bioactive (5S,7S,8R)-N-hydroxy-8-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-oxaspiro[4.4]nonane-7-carboxamide
CFAMM00405281 CHEMBL256621 Bioactive (3R,4S)-N-hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]oxolane-3-carboxamide
CFAMM00405287 CHEMBL401471 Bioactive (5R,7S,8R)-N-hydroxy-8-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-oxaspiro[4.4]nonane-7-carboxamide
CFAMM00405280 CHEMBL272341 Bioactive N-[(1R,2S)-2-(hydroxycarbamoyl)-4-oxocyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
CFAMM00405293 CHEMBL438528 Bioactive N-[(1R,2S,4S)-4-hydroxy-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
CFAMM00405286 CHEMBL253088 Bioactive (3S,4S)-N-hydroxy-3-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]oxane-4-carboxamide
CFAMM00405279 CHEMBL257532 Bioactive N-[(1R,2S,4R)-4-hydroxy-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
CFAMM00405292 CHEMBL401263 Bioactive (7S,8R)-N-hydroxy-8-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1,4-dioxaspiro[4.4]nonane-7-carboxamide
CFAMM00405285 CHEMBL254307 Bioactive N-[2-(hydroxycarbamoyl)cyclobutyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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