CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10907
Family Name Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-4-yl)-6-(pyrazin-2-ylamino)pyridin-4-yl]amino]methyl]phenol family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00405326 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Estrogen receptor Binder Superfamily
Class Class 3526

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
PF-4217903 family 14 65
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Tyrosine kinase Inhibitor PKI166 Family 17 198
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-(1h-imidazol-4-yl)be... 2 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 6-chloro-3-(1,3... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Phosphatidylinositol 4-kinase beta inhibitor (4E)-2-fluoro-4-[... 1 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Estrogen receptor beta and Estrogen receptor ligand SureCN6343... 2 1
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 9 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00405326 CHEMBL2069351 Bioactive 4-[[[2-(2-piperazin-1-ylpyridin-4-yl)-6-(pyrazin-2-ylamino)pyridin-4-yl]amino]methyl]phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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