CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10909
Family Name Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4-yl)-6-(pyrazin-2-ylamino)pyridin-4-yl]carbamoyl]benzoic acid family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00405333 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Egl nine homolog 1 Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
JAK Inhibitor Momelotinib Family 33 83
PF-4136309 family 16 27
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 3
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylme... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00405333 CHEMBL2069359 Bioactive 4-[[2-(2-piperazin-1-ylpyridin-4-yl)-6-(pyrazin-2-ylamino)pyridin-4-yl]carbamoyl]benzoic acid
CFAMM00405332 CHEMBL2069360 Bioactive 5-[[2-(2-piperazin-1-ylpyridin-4-yl)-6-(pyrazin-2-ylamino)pyridin-4-yl]carbamoyl]pyridine-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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