CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10917
Family Name Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,4S)-1-(butylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]phenoxy]-N-[3-[(7-chloroquinolin-4-yl)amino]propyl]benzamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00326034 Functional Category Bioactive
Superfamily Plasmepsin-2 and Cathepsin D Binder Superfamily
Class Class 630

Cousin Family NamesSeedsMembers
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Plasmepsin-2 inhibitor N-[(2S)-1-[[(2S)-6-amino-1-[4-[(6-metho... 5 12
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Pol polyprotein inhibitor (2S)-N-[4-[cyclopentyloxy-(4-methoxy... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 4 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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