CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10938
Family Name Translocator protein inhibitor [11C]DAA1106 family
No. of Seeds 15 No. of Other Members 2
Family Centroid CFAMM00405529 Functional Category Bioactive
Superfamily Translocator protein and Nuclear receptor ROR-gamma Binder Superfamily
Class Class 2417

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Beta-secretase 1 inhibitor Coumarin Compound, 10b family 2 0


External ID

Functional Category

Molecule Name

CFAMM00405538 CHEMBL2070811 Bioactive N-(1,3-benzodioxol-4-ylmethyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide
CFAMM00405528 CHEMBL63064 Bioactive DAA-1106
CFAMM00405534 CHEMBL2070788 Bioactive N-(2-cyclopentyloxyphenyl)-N-[(2,5-dimethoxyphenyl)methyl]-2-fluoroacetamide
CFAMM00405537 CHEMBL2070810 Bioactive N-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide
CFAMM00405527 CHEMBL63065 Bioactive AGN-PC-00BWI0
CFAMM00405533 CHEMBL2070800 Bioactive N-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-N-(5-fluoro-2-phenoxyphenyl)acetamide
CFAMM00405536 CHEMBL473435 Bioactive AGN-PC-00EBUM
CFAMM00405542 CHEMBL2070790 Bioactive N-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-N-(2-propan-2-yloxyphenyl)acetamide
CFAMM00405532 CHEMBL72521 Bioactive AGN-PC-008JLQ
CFAMM00405535 CHEMBL292092 Bioactive AGN-PC-0718GO
CFAMM00405541 CHEMBL2070791 Bioactive N-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-N-(5-fluoro-2-propan-2-yloxyphenyl)acetamide
CFAMM00405531 CHEMBL2070808 Bioactive N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide
CFAMM00405530 CHEMBL2070786 Bioactive N-[[5-(2-fluoroethoxy)-2-methoxyphenyl]methyl]-N-(5-fluoro-2-phenoxyphenyl)acetamide
CFAMM00405539 CHEMBL2070812 Bioactive N-[(2,2-dimethyl-3H-1-benzofuran-7-yl)methyl]-2-fluoro-N-(2-phenoxyphenyl)acetamide
CFAMM00405529 CHEMBL401000 Bioactive [11C]DAA1106

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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