CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10948
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform inhibitor (2S)-1-N-[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00169276 Functional Category Bioactive
Superfamily Disintegrin and Cathepsin K Binder Superfamily 2
Class Class 1378

Cousin Family NamesSeedsMembers
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Protease and Capsid scaffolding protein inhibitor AC1LAC7K family 2 5
Disintegrin and metalloproteinase domain-containing protein 17... 23 5
Disintegrin and metalloproteinase domain-containing protein 17... 8 4
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Glucocorticoid receptor ligand (3R)-3-[1-(4-fluorophenyl)indaz... 4 2
RAC-alpha serine/threonine-protein kinase and Mast/stem cell g... 2 0
Prothrombin and Trypsin-1 inhibitor (2S)-1-[(2R)-2-amino-3,3-d... 1 3
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2


External ID

Functional Category

Molecule Name

CFAMM00405591 CHEMBL2216883 Bioactive 3-[[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]carbamoylamino]-N-(3-methyl-2H-pyrrol-5-yl)propanamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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