CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10960
Family Name Microsomal triglyceride transfer protein large subunit inhibitor N-[(1S)-2-(benzylamino)-2-oxo-1-phenylethyl]-3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00405682 Functional Category Bioactive
Superfamily Microsomal triglyceride transfer protein large subunit and Cytochrome P450 3A4 Binder Superfamily
Class Class 2499

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Mitogen-activated protein kinase 14 inhibitor N-[2,4-difluoro-... 4 1
Serine/threonine-protein kinase Chk1 inhibitor 2-[9-(4-amino-3... 5 2
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00405683 CHEMBL207354 Bioactive N-[(1S)-2-(cyclopropylmethylamino)-2-oxo-1-phenylethyl]-3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide
CFAMM00405682 CHEMBL379030 Bioactive N-[(1S)-2-(benzylamino)-2-oxo-1-phenylethyl]-3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide
CFAMM00405681 CHEMBL210652 Bioactive 3-methoxy-N-[(1S)-2-oxo-1-phenyl-2-pyrrolidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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