CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1099
Family Name Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[1-[(4-aminophenyl)methyl]-2,6-dioxo-3-propyl-7H-purin-8-yl]phenoxy]acetic acid family
No. of Seeds 12 No. of Other Members 15
Family Centroid CFAMM00278626 Functional Category Bioactive with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2b Binder Superfamily
Class Class 253

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Vardena... 3 39
Adenosine receptor A2a Ligand KW-6002 Family 18 195
GP-531 family 1 33
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 17 3
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-(5-ethyl-1,2,4... 25 61
Prelamin-A/C inhibitor CHEMBL1501476 family 1 2
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[3-fluoro-4-(5-ph... 10 2
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-[5-(cyclopenty... 27 2
Survival motor neuron protein and Microtubule-associated prote... 2 14
Histamine H3 receptor ligand SureCN7251693 family 3 1
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 10 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (4-nit... 8 2
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
Muscarinic acetylcholine receptor M1 and Nuclear factor NF-kap... 1 12
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Adenosine receptor A1 and Adenosine receptor A2b ligand N-[2-[... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
P2X purinoceptor 7 inhibitor (7R)-1-[(3,4-difluorophenyl)methy... 1 0
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Sodium/hydrogen exchanger 1 inhibitor AGN-PC-078XNL family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00319437 CHEMBL56018 Bioactive ethyl 2-[4-(6-oxo-1,3-dipropyl-2-sulfanylidene-7H-purin-8-yl)phenoxy]acetate
CFAMM00319441 CHEMBL11077 Bioactive 8-(4-butoxyphenyl)-1,3-dimethyl-7H-purine-2,6-dione
CFAMM00319433 CHEMBL268701 Bioactive AC1LIQXH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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