CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10990
Family Name B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyanoacetyl)amino]-4-methylpyridin-2-yl]amino]ethyl]phenyl]benzoate family
No. of Seeds 8 No. of Other Members 7
Family Centroid CFAMM00405917 Functional Category Bioactive
Superfamily B1 bradykinin receptor and Protease Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Coagulation factor X Inhibitor Otamixaban Family 9 21
Smoothened homolog Inhibitor LDE225 Family 3 76
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 22
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QM95 family 1 1
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Neuropeptide Y receptor type 5 ligand 3-[1-(2-fluorophenyl)pyr... 5 4
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 1 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453385 ... 5 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Neutrophil elastase inhibitor AGN-PC-076VCN family 3 25
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Neuropeptide Y receptor type 5 ligand AGN-PC-07CRFU family 18 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
P2Y purinoceptor 12 inhibitor SureCN3928692 family 5 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-006EKH... 1 0
ethyl 4-[[(2S)-2-pyridin-3-ylpiperidine-1-carbothioyl]amino]be... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00405907 CHEMBL2113085 Bioactive methyl 2-[4-[[[4-methyl-3-(3,3,3-trifluoropropanoylamino)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00405914 CHEMBL225133 Bioactive methyl 2-[4-[(1R)-1-[[3-[(2-cyanoacetyl)amino]-4-methylpyridin-2-yl]amino]ethyl]phenyl]-4-methylbenzoate
CFAMM00405906 CHEMBL2113087 Bioactive methyl 2-[4-[(1R)-1-[[4-methyl-3-(3,3,3-trifluoropropanoylamino)pyridin-2-yl]amino]ethyl]phenyl]benzoate
CFAMM00405904 CHEMBL375288 Bioactive methyl 4-chloro-2-[4-[(1R)-1-[[4-chloro-3-[(2-cyanoacetyl)amino]pyridin-2-yl]amino]ethyl]phenyl]benzoate
CFAMM00405917 CHEMBL2113091 Bioactive methyl 2-[4-[(1R)-1-[[3-[(2-cyanoacetyl)amino]-4-methylpyridin-2-yl]amino]ethyl]phenyl]benzoate
CFAMM00405909 CHEMBL208371 Bioactive methyl 2-[4-[[[3-[(2-cyanoacetyl)amino]-4-methylpyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00405915 CHEMBL221998 Bioactive methyl 2-chloro-6-[4-[(1R)-1-[[4-chloro-3-[(2-cyanoacetyl)amino]pyridin-2-yl]amino]ethyl]phenyl]benzoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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