CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11011
Family Name Platelet-derived growth factor receptor alpha and Vascular endothelial growth factor receptor 2 ligand 3-[1,3-dihydrobenzimidazol-2-ylidene-(4-methoxyphenyl)methyl]-5-[(1-ethylpiperidin-4-yl)amino]indol-2-one family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00226306 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 and Telomerase reverse transcriptase Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Epidermal Growth Factor family 111 209
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Histamine H1 receptor Ligand Mizolastine Family 14 603
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
BIBT986 family 7 96
CC-486 family 7 103
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Renin Inhibitor Enalkiren Family 56 44
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-7-[1H-b... 3 6
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 1 6
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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