CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11014
Family Name Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-phenacyl-N-(2-piperidin-1-ylethyl)pyrrolo[3,2-c]quinoline-2-carboxamide family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00406121 Functional Category Bioactive
Superfamily Sonic hedgehog protein and 3-hydroxyacyl-CoA dehydrogenase type-2 Binder Superfamily
Class Class 2433

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor AGN-PC-09M9MJ family 2 23
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Sonic hedgehog protein inhibitor 6-ethyl-3-(2-fluoroethoxy)-N-... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melanin-concentrating hormone receptor 1 ligand 6-[3-methoxy-4... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406121 CHEMBL2086802 Bioactive 3-methoxy-1-methyl-4-oxo-5-phenacyl-N-(2-piperidin-1-ylethyl)pyrrolo[3,2-c]quinoline-2-carboxamide
CFAMM00406120 CHEMBL2086805 Bioactive N-[1-(2-hydroxyethyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-phenacylpyrrolo[3,2-c]quinoline-2-carboxamide
CFAMM00406119 CHEMBL2086801 Bioactive 3-ethoxy-1-methyl-4-oxo-5-phenacyl-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,2-c]quinoline-2-carboxamide
CFAMM00406125 CHEMBL2087239 Bioactive N-[1-(2-hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-phenacylpyrrolo[3,2-c]quinoline-2-carboxamide
CFAMM00406118 CHEMBL2086800 Bioactive 3-methoxy-1-methyl-4-oxo-5-phenacyl-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,2-c]quinoline-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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