CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11033
Family Name Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-oxolan-2-yl]methylamino]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]benzenesulfonamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00406318 Functional Category Bioactive
Superfamily Activated CDC42 kinase 1 Binder Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Tyrosine kinase Inhibitor PKI166 Family 17 198
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine kinase inhibitor GP683 family 12 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 3 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406318 CHEMBL2087652 Bioactive N,N-dimethyl-4-[4-[[(2S)-oxolan-2-yl]methylamino]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]benzenesulfonamide
CFAMM00406317 CHEMBL2087651 Bioactive 6-(4-methylsulfonylphenyl)-N-[[(2S)-oxolan-2-yl]methyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CFAMM00406316 CHEMBL2087654 Bioactive N-methyl-4-[4-[[(2S)-oxolan-2-yl]methylamino]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]benzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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