CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11041
Family Name Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00406366 Functional Category Bioactive
Superfamily Substance-P receptor and C-C chemokine receptor type 3 Binder Superfamily
Class Class 2044

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Vestipitant Family 14 137
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Nociceptin receptor Ligand J-113397 Family 3 14
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
Calcitonin gene-related peptide type 1 receptor ligand N,N-dim... 12 32
Cannabinoid receptor 2 ligand SureCN738026 family 5 68
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-anilinopyrr... 2 13
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
C-C chemokine receptor type 3 ligand 4-(5-amino-2-oxo-3H-benzi... 1 0
C-C chemokine receptor type 3 ligand (2S)-1-N-[(1R,5R)-8-[(6-f... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Coagulation factor VII and Prothrombin inhibitor 2-[(4-carbami... 2 1
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 2 0
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL6C family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406366 CHEMBL2088035 Bioactive 2-[3-[1-[(1R)-1,2-dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide
CFAMM00406365 CHEMBL222634 Bioactive 2-[1-methyl-3-(2-oxo-4,4-diphenylimidazolidin-1-yl)pyrrolidin-1-ium-1-yl]-N-phenylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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