CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11046
Family Name Fibroblast growth factor receptor 1 and Vascular endothelial growth factor receptor 2 ligand 4-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-N-[(5-methyl-1,2-oxazol-3-yl)methyl]pyrimidine-2,4-diamine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00406384 Functional Category Bioactive
Superfamily Aurora kinase A and GABA theta subunit Binder Superfamily
Class Class 1228

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 16
Vascular endothelial growth factor receptor 1 and Fibroblast g... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor ... 8 8
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38795 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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