CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11055
Family Name Melanin-concentrating hormone receptor 1 and Muscarinic acetylcholine receptor M3 ligand 6-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyridazin-7-one family
No. of Seeds 8 No. of Other Members 2
Family Centroid CFAMM00335719 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Prelamin-A/C and Niemann-Pick C1 protein inhibitor CHEMBL13592... 1 16
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino... 5 6
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand N-... 2 17
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 7 11
Adenosine receptor A1 ligand SureCN1497799 family 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL74 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Calcitonin gene-related peptide type 1 receptor ligand N-(1-me... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406474 CHEMBL512657 Bioactive 6-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]thieno[2,3-c]pyridin-7-one
CFAMM00406466 CHEMBL378869 Bioactive 2-(4-fluorophenyl)-6-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]thieno[2,3-d]pyridazin-7-one
CFAMM00406472 CHEMBL208845 Bioactive 6-[6-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyridazin-7-one
CFAMM00406470 CHEMBL211340 Bioactive 2-(4-ethylphenyl)-6-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]thieno[2,3-d]pyridazin-7-one
CFAMM00406469 CHEMBL377588 Bioactive 2-(4-chlorophenyl)-6-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]thieno[2,3-d]pyridazin-7-one
CFAMM00406468 CHEMBL379933 Bioactive 2-(4-fluorophenyl)-6-[6-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]thieno[2,3-d]pyridazin-7-one
CFAMM00406475 CHEMBL426507 Bioactive 6-[6-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyridazin-7-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48689 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543