CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11056
Family Name Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-yl-1,3-benzoxazol-3-yl)-N-phenylacetamide family
No. of Seeds 8 No. of Other Members 15
Family Centroid CFAMM00406498 Functional Category Bioactive
Superfamily Chymase and Liver carboxylesterase 1 Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Histamine H3 receptor and Cytochrome P450 3A4 ligand SureCN822... 3 7
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Nischarin inhibitor SureCN7810370 family 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
P2X purinoceptor 7 inhibitor 3-[1-[4-(3-nitrophenyl)phenoxy]-4... 1 1
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406497 CHEMBL2088540 Bioactive N-methyl-2-(2-oxo-5-pyridin-2-yl-1,3-benzoxazol-3-yl)-N-phenylacetamide
CFAMM00406485 CHEMBL2442942 Bioactive N-ethyl-2-(2-oxo-5-pyridin-4-yl-1,3-benzoxazol-3-yl)-N-phenylacetamide
CFAMM00406496 CHEMBL2442937 Bioactive N-methyl-2-[2-oxo-5-[4-(trifluoromethoxy)phenyl]-1,3-benzoxazol-3-yl]-N-pyridin-3-ylacetamide
CFAMM00406489 CHEMBL2442944 Bioactive N-methyl-2-(2-oxo-5-pyridin-4-yl-1,3-benzoxazol-3-yl)-N-[4-(trifluoromethyl)phenyl]acetamide
CFAMM00406495 CHEMBL2442936 Bioactive N-methyl-2-[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3-yl]-N-pyridin-3-ylacetamide
CFAMM00406487 CHEMBL2442940 Bioactive N-methyl-2-(2-oxo-5-pyridin-3-yl-1,3-benzoxazol-3-yl)-N-[4-(trifluoromethyl)phenyl]acetamide
CFAMM00406493 CHEMBL2442938 Bioactive N-ethyl-2-(2-oxo-5-pyridin-3-yl-1,3-benzoxazol-3-yl)-N-phenylacetamide
CFAMM00406498 CHEMBL2088542 Bioactive N-methyl-2-(2-oxo-5-pyridin-4-yl-1,3-benzoxazol-3-yl)-N-phenylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22057 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543