CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11064
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A ligand N-[(3S)-1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,5-dioxopyrrolidin-3-yl]adamantane-1-carboxamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00179105 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Superfamily
Class Class 1389

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Calcitonin gene-related peptide type 1 receptor ligand 2-(4-me... 4 4
Gonadotropin-releasing hormone receptor ligand CHEMBL260816 fa... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406532 CHEMBL424871 Bioactive 2-(3-bicyclo[2.2.1]heptanyl)-N-[(3R)-1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,5-dioxopyrrolidin-3-yl]acetamide
CFAMM00406531 CHEMBL210296 Bioactive N-[(3R)-1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,5-dioxopyrrolidin-3-yl]adamantane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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