CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11074
Family Name Coagulation factor X inhibitor AGN-PC-02WFR7 family
No. of Seeds 7 No. of Other Members 13
Family Centroid CFAMM00406644 Functional Category Bioactive
Superfamily Coagulation factor X and Sodium channel protein type 9 subunit alpha Binder Superfamily
Class Class 849

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Coagulation factor X Inhibitor SN429 Family 23 100
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Poly [ADP-ribose] polymerase 1 Inhibitor 2-phenylpyrazolo-[1,5... 1 1
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 3 0
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Coagulation factor X inhibitor 2-(6-chloronaphthalen-2-yl)-5-m... 2 0
Coagulation factor X inhibitor SureCN8169809 family 12 18
Coagulation factor X inhibitor SureCN8168539 family 3 0
Coagulation factor X inhibitor SureCN8166226 family 3 3
Coagulation factor X inhibitor SureCN8165148 family 4 0
Coagulation factor X inhibitor AGN-PC-0749JT family 1 0
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Coagulation factor X inhibitor DPC 423 derivative, 8 family 1 2
Mitogen-activated protein kinase 8 inhibitor 5-[(6-chloro-1-ox... 5 7
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Progesterone receptor ligand AGN-PC-00OK6G family 7 8
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Coagulation factor X inhibitor AGN-PC-046QCP family 2 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Coagulation factor X inhibitor SureCN5254091 family 5 0
Coagulation factor X inhibitor 3kqc family 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Apoptosis regulator Bcl-2 and Bcl2-associated agonist of cell ... 3 3
Ketohexokinase inhibitor 3-carbamimidoyl-N-(3-ethyl-1-phenylin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406627 CHEMBL21179 Bioactive SureCN8164238
CFAMM00406633 CHEMBL279486 Bioactive AGN-PC-00FI0B
CFAMM00406626 CHEMBL20897 Bioactive SureCN8167946
CFAMM00406639 CHEMBL2092985 Bioactive 2-(3-fluoronaphthalen-2-yl)-N-[2-fluoro-4-(pyrrolidine-1-carboximidoyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide
CFAMM00406635 CHEMBL20934 Bioactive AGN-PC-0749LL
CFAMM00406644 CHEMBL21140 Bioactive AGN-PC-02WFR7
CFAMM00406628 CHEMBL21052 Bioactive SureCN8164228

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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