CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11079
Family Name Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 family
No. of Seeds 6 No. of Other Members 12
Family Centroid CFAMM00406670 Functional Category Bioactive
Superfamily Progesterone receptor and D(2) dopamine receptor Binder Superfamily 2
Class Class 667

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
JNJ-39439335 family 5 11
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Transient receptor potential cation channel subfamily M member... 9 0
Transient receptor potential M8 protein and Cytochrome P450 2C... 4 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Transient receptor potential cation channel subfamily V member... 4 0
Transient receptor potential cation channel subfamily V member... 6 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Melanin-concentrating hormone receptor 1 ligand 3-[(1S,4R,5S)-... 3 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Transient receptor potential cation channel subfamily V member... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromet... 1 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Prostaglandin E synthase inhibitor AGN-PC-04SSMB family 6 0
Small conductance calcium-activated potassium channel protein ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406665 CHEMBL211672 Bioactive 3-[4-[[1-(cyclopropylmethyl)piperidin-4-ylidene]-[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]methyl]phenyl]-4-fluorobenzonitrile
CFAMM00406658 CHEMBL209993 Bioactive AGN-PC-00ED2X
CFAMM00406670 CHEMBL209109 Bioactive AGN-PC-00BSP9
CFAMM00406669 CHEMBL209103 Bioactive 3-[4-[[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-[1-(2-hydroxyethyl)piperidin-4-ylidene]methyl]phenyl]benzonitrile
CFAMM00406666 CHEMBL377843 Bioactive SureCN14502088
CFAMM00406672 CHEMBL212256 Bioactive SureCN5383958

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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