CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11080
Family Name Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophenyl)-2-[6-[(3S)-3-(ethylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00406683 Functional Category Bioactive
Superfamily Reverse transcriptase/RNaseH and ALK tyrosine kinase receptor Binder Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Class II cytokine receptor Ligand IL-10 Family 7 45
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-0... 18 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Tyrosine-protein kinase ABL1 inhibitor 5-[(5-{[4-{[4-(2-Hydrox... 4 1
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 13 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Substance-P receptor ligand Netupitant family 5 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Transient receptor potential cation channel subfamily V member... 57 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-X-C chemokine receptor type 3 ligand AGN-PC-07CQOB family 17 10
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 3 6
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Transient receptor potential cation channel subfamily V member... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406680 CHEMBL210926 Bioactive 2-[6-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]-6-[4-(trifluoromethyl)phenyl]phthalazin-1-one
CFAMM00406679 CHEMBL210191 Bioactive 6-(4-chlorophenyl)-2-[6-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one
CFAMM00406678 CHEMBL378309 Bioactive 2-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]-6-[4-(trifluoromethyl)phenyl]phthalazin-1-one
CFAMM00406684 CHEMBL209110 Bioactive 6-(4-chlorophenyl)-2-[6-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one
CFAMM00406677 CHEMBL212053 Bioactive 6-(4-chlorophenyl)-2-[6-[(3S)-3-(pyrrolidin-1-ylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one
CFAMM00406683 CHEMBL209172 Bioactive 6-(4-chlorophenyl)-2-[6-[(3S)-3-(ethylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one
CFAMM00406682 CHEMBL379189 Bioactive 6-(4-chlorophenyl)-2-[6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one
CFAMM00406681 CHEMBL211223 Bioactive 6-(4-chlorophenyl)-2-[6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-3-yl]phthalazin-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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