CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11102
Family Name Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-phenylchromen-4-one family
No. of Seeds 14 No. of Other Members 6
Family Centroid CFAMM00406793 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Adenosine receptor A1 Binder Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand 4-(piperazin-1-yl)furo[... 3 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Melanin-concentrating hormone receptor 1 ligand 2-(4-methoxyph... 1 0
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Reverse transcriptase/RNaseH inhibitor PETT deriv. 14 family 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 4


External ID

Functional Category

Molecule Name

CFAMM00406796 CHEMBL213932 Bioactive 7-(4-chlorophenyl)-3-[6-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one
CFAMM00406809 CHEMBL438792 Bioactive 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-(4-fluorophenyl)chromen-4-one
CFAMM00406802 CHEMBL214221 Bioactive 7-(4-chloro-2-methylphenyl)-3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one
CFAMM00406808 CHEMBL378230 Bioactive 7-(4-bromophenyl)-3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one
CFAMM00406801 CHEMBL213540 Bioactive 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-[4-(trifluoromethyl)phenyl]chromen-4-one
CFAMM00406807 CHEMBL377479 Bioactive 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-(4-ethylphenyl)chromen-4-one
CFAMM00406800 CHEMBL534717 Bioactive 7-(4-chlorophenyl)-3-[6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one;hydrochloride
CFAMM00406793 CHEMBL209542 Bioactive 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-phenylchromen-4-one
CFAMM00406806 CHEMBL210069 Bioactive 7-(4-chlorophenyl)-3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one
CFAMM00406792 CHEMBL212758 Bioactive 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-(4-methoxyphenyl)chromen-4-one
CFAMM00406791 CHEMBL213949 Bioactive 7-(1,3-benzodioxol-5-yl)-3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one
CFAMM00406804 CHEMBL209416 Bioactive 7-(4-chloro-3-methylphenyl)-3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one
CFAMM00406797 CHEMBL385141 Bioactive 3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]-7-(4-methoxy-2-methylphenyl)chromen-4-one
CFAMM00406803 CHEMBL213459 Bioactive 7-(2,3,4a,5,8,8a-hexahydro-1,4-benzodioxin-6-yl)-3-[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]chromen-4-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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