CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11103
Family Name Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimidine, 26 family
No. of Seeds 15 No. of Other Members 0
Family Centroid CFAMM00406813 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 3679

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand Napht... 5 14
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... 2 6
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Cell division cycle 7-related protein kinase and Dual specific... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 5 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00406821 CHEMBL213846 Bioactive pyrimido-pyrimidine, 30
CFAMM00406814 CHEMBL209442 Bioactive pyrimido-pyrimidine, 43
CFAMM00406820 CHEMBL212803 Bioactive pyrimido-pyrimidine, 41
CFAMM00406813 CHEMBL441853 Bioactive pyrimido-pyrimidine, 26
CFAMM00406819 CHEMBL212821 Bioactive pyrimido-pyrimidine, 24
CFAMM00406812 CHEMBL212937 Bioactive pyrimido-pyrimidine, 20
CFAMM00406818 CHEMBL214138 Bioactive pyrimido-pyrimidine, 28
CFAMM00406811 CHEMBL212753 Bioactive pyrimido-pyrimidine, 19
CFAMM00406824 CHEMBL212091 Bioactive pyrimido-pyrimidine, 40
CFAMM00406817 CHEMBL213190 Bioactive pyrimido-pyrimidine, 32
CFAMM00406823 CHEMBL213142 Bioactive pyrimido-pyrimidine, 35
CFAMM00406810 CHEMBL213895 Bioactive pyrimido-pyrimidine, 27
CFAMM00406816 CHEMBL211795 Bioactive pyrimido-pyrimidine, 34
CFAMM00406822 CHEMBL425785 Bioactive pyrimido-pyrimidine, 25
CFAMM00406815 CHEMBL377979 Bioactive pyrimido-pyrimidine, 42

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27291 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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