CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11130
Family Name Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-3-methyl-6-oxocyclohexa-1,3-dien-1-yl]-4-hydroxyphenyl]methylurea family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00407023 Functional Category Bioactive
Superfamily Coagulation factor VII and Urokinase-type plasminogen activator Binder Superfamily
Class Class 931

Cousin Family NamesSeedsMembers
JNJ-39439335 family 5 11
Tyrosine kinase Inhibitor PKI166 Family 17 198
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49
Coagulation factor VII inhibitor 2-[(3E)-3-(5-carbamimidoyl-1,... 3 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Serine/threonine-protein kinase Chk1 inhibitor 6-chloro-3-(1,3... 4 2
Coagulation factor VII inhibitor AGN-PC-0763KB family 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 8 21
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Coagulation factor X and Urokinase-type plasminogen activator ... 8 10
Coagulation factor VII and Tissue factor inhibitor 2-[3-(5-car... 3 2
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Tyrosine-protein kinase Lck inhibitor 6,7-dimethyl-2-(2,4,6-tr... 1 0


External ID

Functional Category

Molecule Name

CFAMM00407023 CHEMBL209791 Bioactive [3-[(5E)-5-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-3-methyl-6-oxocyclohexa-1,3-dien-1-yl]-4-hydroxyphenyl]methylurea
CFAMM00407022 CHEMBL378947 Bioactive [3-[(5E)-5-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-3-fluoro-6-oxocyclohexa-1,3-dien-1-yl]-4-hydroxyphenyl]methylurea
CFAMM00407027 CHEMBL73737 Bioactive (2E)-2-[5-(3-aminophenyl)-3-chloro-6-oxocyclohexa-2,4-dien-1-ylidene]-1,3-dihydrobenzimidazole-5-carboximidamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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