CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11132
Family Name RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(2-methyl-1-thiophen-2-ylpropan-2-yl)-1,3-dihydroindol-2-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00407065 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and Nuclear receptor ROR-gamma Binder Superfamily
Class Class 3208

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407066 CHEMBL572884 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-thiophen-2-yl-1,3-dihydroindol-2-one
CFAMM00407065 CHEMBL209826 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(2-methyl-1-thiophen-2-ylpropan-2-yl)-1,3-dihydroindol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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