CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11141
Family Name Serine/threonine-protein kinase Chk1 inhibitor 6-chloro-3-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[(3S)-pyrrolidin-3-yl]amino]quinolin-2-one family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00407104 Functional Category Bioactive
Superfamily Lysosomal Pro-X carboxypeptidase and Serine/threonine-protein kinase Chk1 Binder Superfamily
Class Class 1016

Cousin Family NamesSeedsMembers
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 8 21
Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11
Tyrosine-protein kinase Lck inhibitor 6,7-dimethyl-2-(2,4,6-tr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407102 CHEMBL210639 Bioactive SureCN6390590
CFAMM00407101 CHEMBL210035 Bioactive 6-chloro-3-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[(3R)-pyrrolidin-3-yl]amino]quinolin-2-one
CFAMM00407106 CHEMBL381952 Bioactive SureCN6390082
CFAMM00407104 CHEMBL209982 Bioactive 6-chloro-3-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[(3S)-pyrrolidin-3-yl]amino]quinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26232 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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