CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11147
Family Name RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(1H-imidazol-2-yl)-1,3-dihydroindol-2-one family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00407144 Functional Category Bioactive
Superfamily MK-3328 Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Epidermal Growth Factor family 111 209
Melatonin receptor type 1A Ligand Melatonin Family 20 988
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
PF-02545920 family 16 140
Eluxadoline family 4 85
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Renin Inhibitor Enalkiren Family 56 44
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor 3-(hydroxy... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407145 CHEMBL210209 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[1-(1H-imidazol-2-yl)-2-methylpropan-2-yl]-1,3-dihydroindol-2-one
CFAMM00407144 CHEMBL579053 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(1H-imidazol-2-yl)-1,3-dihydroindol-2-one
CFAMM00407143 CHEMBL575385 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-1,3-dihydropyrrolo[2,3-b]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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