CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11148
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand Piperazine, 1-(2-methoxyphenyl)-4-[(1-phenyl-1H-pyrazol-4-yl)methyl]- family
No. of Seeds 3 No. of Other Members 14
Family Centroid CFAMM00298347 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Prelamin-A/C Binder Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUW... 2 9
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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