CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1115
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor ligand SureCN9248869 family
No. of Seeds 14 No. of Other Members 12
Family Centroid CFAMM00179504 Functional Category Bioactive with Natural Product
Superfamily Alpha-1A adrenergic receptor Ligand Naftopidil Superfamily
Class Class 1071

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Cholesteryl ester transfer protein Inhibitor CP-800569 Family 5 81
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
Multidrug resistance protein Inhibitor MM36 Family 1 1
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 7
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-aminonaphthalen-1-ol... 2 34
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 1A and D(4) dopamine receptor lig... 1 0
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Progesterone receptor ligand CHEMBL252850 family 2 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN6779516 ... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Mitogen-activated protein kinase 14 inhibitor ITX 5061 free ba... 2 3
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Amyloid beta A4 protein inhibitor 2-[(4-bromophenyl)methyl]-3-... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand Sure... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3
NP (e)-4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)vinyl)-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46009 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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