CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1119
Family Name 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine receptor 1D ligand SureCN8694602 family
No. of Seeds 5 No. of Other Members 13
Family Centroid CFAMM00179515 Functional Category Bioactive
Superfamily C-C chemokine receptor type 1 Ligand BX-471 Superfamily
Class Class 217

Cousin Family NamesSeedsMembers
Beta-2 adrenergic receptor Ligand Formoterol Family 16 63
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Transient receptor potential cation channel subfamily V member... 3 15
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2K family 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 16 6
Transient receptor potential cation channel subfamily V member... 1 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Melanin-concentrating hormone receptor 1 ligand 3-[4-fluoro-3-... 3 7
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
C-C chemokine receptor type 3 ligand 1-[(3R)-1-[(6-fluoronapht... 2 6
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
Cholinesterase inhibitor (13-methyl-5,6,8,13a-tetrahydroisoqui... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00319669 CHEMBL175634 Bioactive 1-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(2-methoxyphenyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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