CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11190
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ligand 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione family
No. of Seeds 23 No. of Other Members 10
Family Centroid CFAMM00407440 Functional Category Bioactive
Superfamily Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor Binder Superfamily 5
Class Class 1558

Cousin Family NamesSeedsMembers
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407429 CHEMBL61483 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione
CFAMM00407442 CHEMBL43921 Bioactive 3-[2-(8-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407448 CHEMBL289361 Bioactive 3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407428 CHEMBL41444 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-chloro-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407441 CHEMBL290388 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-8-carboxamide
CFAMM00407454 CHEMBL40780 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-7-carbonitrile
CFAMM00407447 CHEMBL40564 Bioactive 3-[3-(6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)propyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407427 CHEMBL291154 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-9-chloro-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407440 CHEMBL2112073 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407433 CHEMBL289166 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-9-carbonitrile
CFAMM00407446 CHEMBL40310 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-methyl-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407426 CHEMBL290519 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-N,N-dimethyl-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-8-carboxamide
CFAMM00407432 CHEMBL289758 Bioactive 3-[4-(6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)butyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407445 CHEMBL289627 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-6-carbonitrile
CFAMM00407438 CHEMBL40819 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-nitro-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407451 CHEMBL43573 Bioactive methyl 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-8-carboxylate
CFAMM00407431 CHEMBL41155 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-8-carbonitrile
CFAMM00407450 CHEMBL39037 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-9-methyl-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407443 CHEMBL41344 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-9-methoxy-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407456 CHEMBL291073 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-[1]benzothiolo[3,2-d]pyrimidine-7-carboxamide
CFAMM00407449 CHEMBL434591 Bioactive 3-[2-(9-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
CFAMM00407436 CHEMBL43234 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7-(trifluoromethyl)-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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