CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11205
Family Name Substance-P receptor ligand (3S)-3-[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]-10-phenyl-1-oxa-9-azaspiro[4.5]decane family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00407518 Functional Category Bioactive
Superfamily Substance-P receptor Binder Superfamily 6
Class Class 1248

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Substance-P receptor ligand 5-[[(3S)-3-[2-methoxy-5-[5-(triflu... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0


External ID

Functional Category

Molecule Name

CFAMM00407518 CHEMBL327250 Bioactive (3S)-3-[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]-10-phenyl-1-oxa-9-azaspiro[4.5]decane
CFAMM00407521 CHEMBL2112366 Bioactive (10S)-3-[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]-10-phenyl-1-oxa-9-azaspiro[4.5]dec-3-ene
CFAMM00407514 CHEMBL419119 Bioactive (5S,10S)-5-(4-fluorophenyl)-10-[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]-1,8-dioxa-4-azaspiro[5.5]undecane
CFAMM00407519 CHEMBL329828 Bioactive (3S)-9-(1H-imidazol-5-ylmethyl)-3-[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]-10-phenyl-1-oxa-9-azaspiro[4.5]decane

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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