CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11211
Family Name C-C chemokine receptor type 5 ligand AC1MHRXO family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00407550 Functional Category Bioactive
Superfamily C-C chemokine receptor type 5 Binder Superfamily 10
Class Class 2341

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin receptor Ligand Insulin, Porcine Family 61 205
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Substance-P receptor Ligand GSK424887 Family 8 184
Integrin alpha-4 Inhibitor CDP323 Family 8 17
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Renin Inhibitor Enalkiren Family 56 44
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin inhibitor SureCN5856722 family 3 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
C-C chemokine receptor type 5 ligand (2R)-3-cyclobutyl-2-[(3S,... 9 4
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5
A disintegrin and metalloproteinase with thrombospondin motifs... 1 3
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand (2R)-3-cyclobutyl-2-[(3S,... 2 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Cathepsin K inhibitor CHEMBL2163360 family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Tyrosine-protein kinase JAK2 inhibitor SureCN2601181 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407549 CHEMBL471765 Bioactive (2R)-2-((3S,4S)-3-{[4-(2-Benzyl-1H-imidazol-5-yl)piperidin-1-yl]methyl}-4-phenylpyrrolidin-1-yl)-3-methylbutanoic acid
CFAMM00407554 CHEMBL2112560 Bioactive (2R)-2-[(3S,4S)-3-[[4-(2-benzyl-1H-imidazol-5-yl)piperidin-1-yl]methyl]-4-phenylpyrrolidin-1-yl]-3-cyclopropylpropanoic acid
CFAMM00407553 CHEMBL2112559 Bioactive (2R)-2-[(3S,4S)-3-[[4-(2-benzyl-1H-imidazol-5-yl)piperidin-1-yl]methyl]-4-phenylpyrrolidin-1-yl]-3-cyclobutylpropanoic acid
CFAMM00407551 CHEMBL511154 Bioactive AC1MHRXI
CFAMM00407550 CHEMBL520755 Bioactive AC1MHRXO

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543