CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11216
Family Name Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00407573 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Epidermal growth factor receptor Binder Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Reverse transcriptase Inhibitor PT-109 Family 6 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... 2 6
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407573 CHEMBL211283 Bioactive AGN-PC-0762YG
CFAMM00407574 CHEMBL212632 Bioactive AGN-PC-0762YF

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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