CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11233
Family Name Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxytryptamine receptor 3E ligand (5R)-3-(3-methyl-1-benzofuran-5-yl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00407658 Functional Category Bioactive
Superfamily Muscarinic acetylcholine receptor M2 and Muscarinic acetylcholine receptor M4 Binder Superfamily 2
Class Class 1685

Cousin Family NamesSeedsMembers
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Histone deacetylase 2 Inhibitor N-(2-amino-5-(furan-2-yl)pheny... 3 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 3 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 2
Neuropeptide Y receptor type 5 ligand 3-dibenzofuran-2-yl-1-[(... 1 2
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 0
N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-5-yl]benzamide NP... 7 1


External ID

Functional Category

Molecule Name

CFAMM00407660 CHEMBL2113242 Bioactive (5R)-3-(3-ethyl-1-benzofuran-5-yl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one
CFAMM00407658 CHEMBL2113241 Bioactive (5R)-3-(3-methyl-1-benzofuran-5-yl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one
CFAMM00407655 CHEMBL213137 Bioactive (5S)-3-(2,3-dimethyl-1-benzofuran-5-yl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one
CFAMM00407661 CHEMBL211575 Bioactive (5S)-3-(3-bromo-1-benzofuran-5-yl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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