CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11241
Family Name Growth hormone secretagogue receptor type 1 ligand SureCN3680069 family
No. of Seeds 14 No. of Other Members 42
Family Centroid CFAMM00407768 Functional Category Bioactive with Natural Product
Superfamily Growth hormone secretagogue receptor type 1 and Protein Mdm4 Binder Superfamily
Class Class 851

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Smoothened homolog Inhibitor LDE225 Family 3 76
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Aurora kinase A inhibitor SureCN761045 family 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Cholecystokinin receptor type A ligand 6-[2-[2-(cyclohexylmeth... 2 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36380... 6 0
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
E3 ubiquitin-protein ligase Mdm2 and Protein Mdm4 inhibitor CH... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407754 CHEMBL2113318 Bioactive SureCN3679131
CFAMM00407733 CHEMBL413608 Bioactive N-[(R)-1H-indol-3-yl-[5-[2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]methyl]-2-pyridin-2-ylacetamide
CFAMM00407759 CHEMBL402224 Bioactive SureCN3671931
CFAMM00407772 CHEMBL399648 Bioactive N-[(R)-1H-indol-3-yl-[4-[(4-methoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]methyl]-2-pyridin-2-ylacetamide
CFAMM00407726 CHEMBL376258 Bioactive SureCN3675884
CFAMM00407765 CHEMBL400175 Bioactive N-[(R)-1H-indol-3-yl-[4-[(4-methoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]methyl]pyridine-2-carboxamide
CFAMM00407732 CHEMBL252255 Bioactive pyridin-2-yl N-[(1R)-2-(1H-indol-3-yl)-1-[5-[2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]ethyl]carbamate
CFAMM00407750 CHEMBL277376 Bioactive SureCN3636275
CFAMM00407749 CHEMBL252643 Bioactive SureCN3635887
CFAMM00407762 CHEMBL374643 Bioactive SureCN3634991
CFAMM00407775 CHEMBL266063 Bioactive SureCN3667368
CFAMM00407742 CHEMBL252448 Bioactive N-[(1S)-2-(1H-indol-3-yl)-1-[5-[2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]ethyl]piperidine-4-carboxamide
CFAMM00407755 CHEMBL249639 Bioactive N-[(R)-1H-indol-3-yl-[5-[2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]methyl]pyridine-2-carboxamide
CFAMM00407768 CHEMBL241775 Bioactive SureCN3680069

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543