CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11243
Family Name Growth hormone secretagogue receptor type 1 ligand SureCN3666009 family
No. of Seeds 4 No. of Other Members 14
Family Centroid CFAMM00407789 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Insulin receptor Binder Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Epidermal Growth Factor family 111 209
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
Tedizolid family 2 2
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5472741 f... 1 26
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cholecystokinin receptor type A ligand AGN-PC-09M5EH family 1 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Cholecystokinin receptor type A ligand 6-[2-[2-(cyclohexylmeth... 2 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Renin inhibitor AGN-PC-073MLF family 7 6
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1-phenylimidaz... 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Renin inhibitor AGN-PC-002JXB family 14 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00407796 CHEMBL2113322 Bioactive SureCN3681362
CFAMM00407789 CHEMBL2113325 Bioactive SureCN3666009
CFAMM00407795 CHEMBL2113326 Bioactive SureCN3638122
CFAMM00407794 CHEMBL2113328 Bioactive SureCN3637029

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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